Protein Therapeutics: Understanding the Biophysical Characterization Toolbox

Original Broadcast October 26, 2022

There is no one biophysical tool which answers all the essential research questions about a biologic drug candidate or biomolecule.  There are many tools which analyze thermal stability, such as DSF, DSC, DLS, and CD.  There are tools focused on measuring the size and aggregation state of a protein/biomolecule such as SEC, DLS, AUC, MFI, BMI, and mass photometry.  Additionally, the four levels of protein structure can be assessed via mass spectrometry, CD, FTIR, MMS, HRPF, NMR, CryoEM, and X-ray crystallography.  Which tools are orthogonal, are any measurements more essential than others, and is there one technique to rule them all?

During this webinar, you will hear from four scientists discussing the interplay of the techniques from the biophysical toolbox, how those tools are implemented in their research, and how they decide which technologies to utilize under what conditions.  You will gain perspectives and insights from large biopharma, CDMO, academia, and regulatory for more informed decision-making.  Please join us for a 45-minute conversation with these four experts, followed by a live 15-minute Q&A.