FoxWare Protein Footprinting Software Provides Unique Features to Accurately Track Changes in Amino Acid Solvent Accessibility

GenNext Technolgies

Hydroxyl Radical Protein Footprinting (HRPF) can be analyzed using FoxWare Data Processing Software to map binding interactions between proteins and antibodies. Changes in residue-level oxidation of TNFα between bound (to Adalimumab) and unbound states are calculated based on XIC-level differences validated via 100-400 PSMs per individual peptide. New innovations in the software tool allow automation of residue-level changes with confidence metrics that inform upon spectral quality.