GenNext Technologies
Examine how a differential Fox-based HRPF experiment compared the change in oxidation between an aggregated antibody formulation and a non-aggregated formulation that contained an amino acid excipient. The results showed that peptides involved in the intermolecular interactions for the aggregated samples were protected from •OH modification, whereas with the addition of the amino acid, many of those same peptides were exposed to •OH attack. Armed with this actionable data, drug researchers can make further improvements to antibody design and formulation.
