Thermal Denaturation Analysis of Bovine Serum Albumin over Wide Concentration Range by Microfluidic Modulation Spectroscopy

Secondary Structure Analysis Tools For Measuring Thermal Denaturation

Microfluidic Modulation Spectroscopy (MMS) is a revolutionary new technology capable of highly sensitive and reproducible measurements of protein secondary structure using IR absorbance in the Amide I band (1700-1600 cm-1). MMS is performed on the AQS3pro system from RedShift BioAnalytics, and it generates measurements over a wide range of complex backgrounds, including buffers that contain absorbing materials and scattering components such as reducing agents, adjuvants, surfactants, and other excipients.