Halo Labs
AAV capsids are meta-stable: the protein shell must be strong enough to withstand the drug delivery journey, but rupture once inside the cell to release the therapeutic payload. Compromised AAV capsid integrity can potentially lower product purity and significantly reduce drug efficacy. It is also well established that DNA can promote aggregate formation, a behavior that may be enhanced when DNA leaks out of the AAV protein capsid. In this application note, learn how Aura GT can characterize your viral vector therapy for stability and aggregation with just 5 µL of sample. Take a deeper dive and detect free DNA to understand the root cause of viral vector instability.
